The core infrastructure of the Microbiota Therapeutics Outcomes Program is supported by a University of Toronto Department of Medicine Integrating Challenge Grant.

There are four funded studies currently involved with the MTOP.

1. Long-term Measurement of Multidisciplinary Outcomes in Patients Receiving Fecal Microbiota Transplantation (FMT) in the University of Toronto Microbiota Therapeutics Outcomes Program (MTOP)

Co-Principal Investigators: Drs. Susy Hota and Susan Poutanen

Funding Agency:  Department of Medicine Integrating Challenge Grant Program

Contact person:  Satyender Singh, satyender.singh@uhnresearch.ca / 416-340-4800 ext. 8353

2. Fecal microbiota transplant from healthy lean donors to morbidly obese individuals: effect on insulin resistance and other obesity-related parameters. A randomized controlled trial.

Principal Investigator: Dr. Johane Allard

Funding Agency: CIHR

Description: Our hypothesis is that a fecal transplant from healthy lean donors into morbidly obese subjects will lead to an improvement in glucose metabolism and to a reduction in body weight, appetite, and food intake as well as to an improvement in quality of life, depression and anxiety scores. This is an ongoing study and recruitment is still active.

Contact person: Katherine Schwenger,  Katherine.Schwenger@uhnresearch.ca / 416-340-4413

3. A Randomized Controlled Trial of the Safety and Efficacy of Fecal Microbiota Transplantation in a Population with Bipolar Disorder

Principal investigator: Dr. Valerie Taylor

Funding Agency: The Stanley Medical Research Institute (SMRI)

Contact person: Teresa Bianco, Teresa.Bianco@wchospital.ca / 416-351-3732 ext. 2301

4. Effectiveness of Fecal Flora Alteration for Eradication of Carbapenemase-Producing Enterobacteriaceae Colonization Trial (EFFECT-CPE): A Multisite, Open-Label, Randomized Controlled Feasibility Pilot Trial

Principal investigators: Drs. Susy Hota and Susan Poutanen

Funding Agency: Physicians Services Incorporated (PSI) Foundation

Contact person: Satyender Singh, satyender.singh@uhnresearch.ca / 416-340-4800 ext. 8353